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FoundMyFitness

Rhonda Patrick, Ph.D.

35 episodes

Oct 14, 2020

Dr. Giselle Petzinger on Exercise for Parkinson's Disease 

Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California and today’s guest, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.

Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.

In this episode, we discuss...

  • 00:06:57 - What is Parkinson’s disease?
  • 00:11:57 - How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1
  • 00:14:57 - How other circuits in the brain can compensate for the loss of function of the substantia nigra.
  • 00:18:37 - Prevalence and hereditary risk factors of Parkinson’s disease.
  • 00:21:25 - How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1
  • 00:26:57 - How exercise can lower the risk of developing Parkinson’s disease. 1 2 3
  • 00:35:38 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space.
  • 00:47:49 - How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2
  • 00:58:33 - How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1
  • 01:01:31 - Why exercise may not fully replace the use of medications.
  • 01:09:58 - How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4
  • 01:12:12 - How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1

Click here to get this episode's show notes and transcript

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Sep 2, 2020

Aliquot #2: Q&A Mashup - Sauna 

Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use.

What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.

This collection of clips covers some of the many health benefits associated with sauna use, including heat shock protein activation, cardiovascular health, muscle mass preservation, and more.

Episode Highlights

  • 00:07:00 - What are the effects of sauna and hot baths on heat shock proteins and the immune system?

  • 00:16:14 - What are your recommendations for infrared sauna temperature and time?

  • 00:24:03 - At what temperature and how long do you need to stay in the sauna to activate heat shock proteins?

  • 00:26:50 - Does sauna use promote excretion of heavy metals such as arsenic?
  • 00:29:12 - Are there ways of mimicking sauna use without regular access to a sauna?

  • 00:33:55 - If compounds such as metformin, resveratrol and vitamin E counteract exercise-induced hormesis, would this be true for other stressors such as the sauna, fasting, broccoli sprouts, polyphenols?

  • 00:37:06 - How does fasting affect human growth hormone and IGF-1 in respect to muscle mass?

  • 00:43:30 - Can saunas be used during fasting to preserve more muscle and increase fat burning?

  • 00:45:50 - Can saunas be used to treat headaches?

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Aug 25, 2020

The Biology of Breast Milk 

This episode aims to be the most comprehensive compendium on the biology of breast milk ever recorded. Looking at the converging clinical and animal evidence of the impact of breast milk paints a complex and beautiful mosaic of developmentally supportive effects that range from allowing the mother to act as a “compensatory” immune system to possibly supporting the development of entire organ systems through the integration of maternal stem cells found in breast milk.

Episode Highlights

  • 00:07:11 - Breast milk composition and production
  • 00:09:59 - Human milk oligosaccharides in breast milk establish the infant gut microbiome
  • 00:15:48 - Omega-3 fatty acids and other components in breast milk boost brain development
  • 00:18:14 - Vitamins and minerals in breast milk
  • 00:22:05 - Breast milk stem cells and multi-organ microchimerism
  • 00:22:54 - Harmful substances transferred to infant via breast milk
  • 00:28:03 - The effects of breastfeeding on the infant's immune system
  • 00:31:17 - Effects on intelligence
  • 00:34:36 - Breastfeeding as a benefit to maternal health

Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.

Breastmilk and breast feeding is now a dedicated Topic section on the website. View that article by clicking here.

Did you enjoy this episode? If you’re interested in learning more about this topic, check out a preview of our very first Aliquot episode: Aliquot #001: Pregnancy & Child Development. It features a compilation of pregnancy and child development-related topics taken from several Q&A episodes over the last couple of years.

Jun 10, 2020

COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More 

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.

Some of the topics that came up as a result of the questions submitted include:

  • 00:04:03 - Data surrounding SARS-CoV-2 duration
  • 00:06:37 - SARS-CoV-2 and potential immunity
  • 00:11:35 - Some of the main factors known to play a role in immune variation
  • 00:12:05 - What role genetics may play in immune function
  • 00:14:27 - How previous viral exposure regulates immunity
  • 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2
  • 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance
  • 00:21:50 - How sleep is a key regulator of immune function
  • 00:23:44 - Microbiome composition and immune function
  • 00:28:31 - The differential effects of exercise intensity and duration on immune regulation
  • 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation
  • 00:47:20 - The effect of sex hormones on immune function
  • 00:48:55 - How biological age age may play a role in immune regulation
  • 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
  • 00:53:15 - ARDS and long-term lung damage

Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.

This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out.

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May 13, 2020

Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More 

In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!

Episode Timeline (abridged)

  • 00:07:33 - Background on vitamin C
  • 00:17:09 - Bioavailability of vitamin C [including dosing frequency]
  • 00:22:53 - Vitamin C in the context of the common cold
  • 00:28:09 - Vitamin C and lung function
  • 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation]
  • 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity
  • 00:48:44 - Vitamin C and the brain
  • 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection
  • 00:55:33 - Intravenous Vitamin C and cancer
  • 00:57:40 - Effect of Vitamin C on fertility and reproduction
  • 00:58:36 - Intravenous vitamin C and cardiovascular health
  • 01:00:42 - Vitamin C and inflammation
  • 01:02:38 - Vitamin C’s mechanisms of action
  • 01:08:34 - Intravenous and Oral vitamin C safety
  • 01:10:20 - Vitamin C intake and kidney stone risk
  • 01:13:57 - Conclusions

Get the full timeline, show summary, and all references for this episode by clicking here.

View our new 28-page vitamin C overview article with over 190 references by clicking here.

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Apr 14, 2020

COVID-19 Q&A #1 with Rhonda Patrick, Ph.D. 

This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon.

Some of the questions we selected from the batch to cover in this episode include:

  • 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission?
  • 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore?
  • 00:17:58 - Can you talk about quercetin's role as a zinc ionophore?
  • 00:20:51 - Is there any indication blood type influences COVID-19 risk?
  • 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection?
  • 00:43:45 - Can you discuss whether sauna use might help prevent COVID19?
  • 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19?
  • 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress?

To supplement this podcast Q&A, we’ve also made a video, summary, timeline, and references. You can view all of these on the episodes page on my website at foundmyfitness.com/episodes/covid-19-qa-1.

If you enjoy this question & answer format, consider joining my premium membership community! Non-COVID-19 related Q&As happen monthly, you get access to an an exclusive bi-weekly science digest email, and much more more! Click here to learn about premium.

Jan 6, 2020

New Omega-3, sulforaphane research, and more! [Kevin Rose Show] 

This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.

In this episode, we discuss...

  • 00:08:00 - Omega-3
  • 00:27:23 - Metformin
  • 00:50:05 - Sulforaphane
  • 01:06:57 - Magnesium L-Threonate
  • 01:13:44 - Sauna
  • 01:23:48 - New FMF Membership

Learn more about the new premium membership.

Learn more about sauna on our overview page.

Learn more about metformin on our overview page.

Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:

Dec 30, 2019

Is Resveratrol a Longevity Compound? 

In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.

Learn more about resveratrol at our comprehensive overview

Relevant timepoints...

  • 00:03:39 - Clinical effects of resveratrol in humans
  • 00:04:10 - Effects on cardiovascular health biomarkers in humans
  • 00:06:54 - Reduction of inflammatory biomarkers in humans
  • 00:08:11 - Improved cognition and memory in clinical studies
  • 00:11:23 - Healthspan improvements in animals
  • 00:12:28 - Induction of longevity genes via xenohormesis
  • 00:16:19 - Contradictory effects on exercise-associated benefits
  • 00:20:34 - Various factors that affect resveratrol bioavailability
  • 00:23:09 - Unintentional effects on drug metabolism

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